ГОРЕ

проф. д-р Митко Младенов

Image descriptionName: Mitko Mladenov
Date and place of birth: 17. 02. 1975 in Novo Selo, Republic of Macedonia
Citizenship/Nationality Macedonian
Marital Status: Married, two children
Office address: Institute of Biology, Faculty of Natural Sciences and Mathematics, Arhimedova 6, PO Box 162, “Sv. Kiril i Metodij” University, Skopje, Republic of Macedonia.
Home Address: Mile Pop-Jordanov 31B/5, 1000 Skopje, Republic of Macedonia
Telephone: Office: (++389-2 3249 605), mob: (++389-78 442-612)
Fax: (++389-2 228-141)
E-mail: m.mitko@gmail.com

Language skills: English, German-basic, French-basic, Russian, Bulgarian, Serbian and Macedonian-(mother tongue)

Education - degrees awarded:
1999 Engineer of Biochemistry, Faculty of Natural Sciences and Mathematics, Institute of Biology, “Sv. Kiril i Metodij” University, Skopje, Republic of Macedonia.
1999-2003 Post graduated Master Study at the Department of Biochemistry, Faculty of Natural Sciences and Mathematics, Institute of Biology, “Sv. Kiril i Metodij” University, Skopje, Republic of Macedonia. Title of Master Thesis:
Age-Related Changes in Glutathione Metabolism at Heat-Stressed Rats.
2004-2007 Doctoral Study at the Institute of Biophysics, Bulgarian Academy of Sciences, Sofia, Bulgaria and Institute of Biology, “Sv. Kiril i Metodij” University, Skopje, Republic of Macedonia.
Title of Doctoral Thesis:
“Comparative study of the ghrelin signal chains in human mesentery and g.pig femoral artery”

Professional expirience:
(1999-2008). Assistant:
Institute of Biology, Faculty of Natural Sciences and Mathematics, “Sv. Kiril i Metodij” University, Skopje, Republic of Macedonia.
(2008 - ) Assistant Professor:
Institutes of Biology, Faculty of Natural Sciences and Mathematics, “Sv. Kiril i Metodij” University, Skopje, Republic of Macedonia.

Professional visits & study tours:
2004 (Oct. 1st to Dec. 30th). Institute of Chemistry and Biochemistry, Ernst Moritz Arndt University Greifswald, Germany.
2005-2007 (3 years). Institute for Biophysics, Bulgarian Academy of Sciences Sofia, Bulgaria.
2008 (May 15th to June 15th). Institute for Molecular Neuro-endocrinology, Czech Academy of Science, Prague, Czech Republic.
2008-2009 (Nov 1st to Oct 30th) one year pos-doc. Institute for Cardiovascular Medicine, Faculty for Clinical Medicine, Mannheim, Karls Rupreht University Heidelberg, Germany.
2011 (July 1st to August 31st). Institute for Cardiovascular Medicine, Faculty for Clinical Medicine, Mannheim, Karls Rupreht University Heidelberg, Germany.

Professional membership:
(2001) – Member of the Physiological Society of Macedonia
(2006) – Member of the Biochemical Society of Macedonia

Teaching experience :
As Assistant Teacher:
• General Physiology (Institute of Biology, Faculty of Natural Sciences and Mathematics).
• Selected Subjects in Physiology (Institute of Chemistry, Faculty of Natural Sciences and Mathematics).
• Physiology of Neuro-endocrine system (Institute of Psychology, Faculty of Philosophical Sciences).
As Assistant Professor:
• General Physiology (Institutes of Chemistry and Physics, Faculty of Natural Sciences and Mathematics).
• Cell Biophysics-basic course (Institute of Biology, Faculty of Natural Sciences and Mathematics).
• Mechanisms of intercellular communications (Institute of Biology, Faculty of Natural Sciences and Mathematics).

Scientific experience:

• Whole cell patch clamp
• Perforated patch
• ELISA methods
• Solid phase extraction and isolation of eicosanoids from tissues;
• Cell cultures
• Colorimetric methods.
• Square-wave and cyclic voltammetry.
• Application of voltammetric methods in study of liquid/liquid interface

Referees:

1. Hristo Gagov, PhD, Full Professor
Department of Human and Animal Physiology
Faculty of Biology
St. Kliment Ohridski University of Sofia
8 Dragan Tzankov blvd.
1164 Sofia, BULGARIA
Phone. +3592 8167 311
Fax. +3592 8656 641
e-mail: hgagov@abv.bg

2. Univ. Prof. Dr. Rudolf Schubert
Kardiovaskuläre Physiologie
Zentrum für Biomedizin und Medizintechnik Medizinische Fakultät Mannheim
Universität Heidelberg
Ludolf-Krehl-Str.13-17
68167 Mannheim
Phone: (0621) 383-9640
Fax: (0621) 383-9646
e-mail: rudolf.schubert@medma.uni-heidelberg.de

3. Anton Kossev, PhD, DCs, Full Professor
Institute of Biophysics
Bulgarian Acadmy of Sciences
St. Acad. G. Bontchev Str., Bl. 21,
Sofia-1113, BULGARIA
Phone: +359-2-979 3702v Fax: +359-2-971 2493
e-mail: kossev@bio.bas.bg

Publication list:
A) Selected Publications in Scientific Journals
1. M. Mladenov, K. Hristov, D. Duridanova (2006). Ghrelin suppression of potassium currents in smooth muscle cells of human mesenteric artery. Gen. Physiol. Biophys. 25: 333-338.
2. Mladenov M, Hristov K, Dimitrova D, Schubert R, Gjorgoski I, Duridanova D, and Gagov H. (2008). Ghrelin signaling in guinea pig femoral artery smooth muscle cells. Acta Physiologica; 194, 3;195-206.
3. Dimitrova Z.D., Dimitrov S., Iliev I., Mladenov I.M., Hristov L.K., Mihov N.D., Duridanova B.D., Gagov S.H., Shubert R. (2010). Ghrelin as a contractile regulator of human mesenteric arteries. Journal of Physiology & Pharmacology 61, 4: 383 -390.
4. Leuner K., Heiser H.J., Derksen S., Mladenov I.M., Fehske J.C., Shubert R., Gollasch M., Schneider G., Harteneck C., Chatterjee S.S., Müller E.W. (2010). Simple 2,4 diacylphloroglucinols as TRPC6 activators – identification of a novel pharmacophore. Molecular Pharmacology, 77: 368-377.
5. Mitko Mladenov, Valentin Mirceski, Icko Gjorgoski and Blagoja Jordanoski (2004). Red-ox kinetic measurements of glutathione at the mercury electrode by means of square-wave voltammetry. The role of copper, cadmium and zinc ions. Bioelectrochemistry, 65: 69-76.
6. Francüois Quentel, Valentin Mirceski, Maurice L’Her, Mitko Mladenov, Fritz Scholz, and Catherine Elleouet (2005). Comparative Study of the Thermodynamics and Kinetics of the Ion Transfer Across the Liquid/Liquid Interface by Means of Three-Phase Electrodes. J. Phys. Chem. B: 109, 13228-13236.
7. M. Mladenov, I. Gjorgoski, T. Stafilov, D. Duridanova (2006). Effect of vitamin C on lipid hydroperoxides and carbonyl groups content of rat plasma depending on age and heat exposure. J. Thermal Biol. 31: 588-593.
8. Mitko Mladenov, Vase Tanska, Tanja Vitkovska, Icko Gjorgoski, Suzana Dinevska-Kofkarovska, Trajce Stafilov, Kiril Hristov and Desislava Duridanova (2008). Evidence for the influence of vitamin C on age- and heat exposure-dependent deterioration of biochemical function in rat's liver and kidney. J. Thermal Biol. 33: 431-436.
9. Nikola Hadzi-Petrushev, Nikola Jankulovski, Kiril Hristov, Mitko Mladenov (2011). L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat’s blood plasma. J. Phys. Sci. DOI: 10.1007/s12576-011-0165-8.
10. Hadzi-Petrushev N., Jankulovski N, Milev M, Filipovska P, Gagov H, Mitrov D, Sopi R, Hristov K, Mladenov M (2012). L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent peroxidation in rat's liver and kidney. J. Thermal Biol. DOI: 10.1016/j.jtherbio.2011.12.013.

B) Published contributions to academic conferences
1. Johanna Schleifenbaum, Olga Zavaritskaya, Nadezda Voblova, Torsten Gloe, Reinhard Kluge, Mitko Mladenov, Hristo Gagov, Gabor Fesu’s Christopher S Crean, Aliso Viejo, CA; Rudolf Schubert, Maik Gollasch (2010). Role of KCNQ Channels in Impaired Periadventitial Vasoregulation and Associated Hypertension. High Blood Pressure Research. Scientific Sessions Abstracts. Hypertension 56; p. 434.
2. Ramadan Sopi, Icko Gjorgoski, Mitko Mladenov, Azem Lajçi, and Muharrem Jakupaj (2010). Role of L-Citrulline/L-Arginine Cycle in Hyperoxia-Induced Decrease of Airway Smooth Muscle Relaxation FASEB J; 24: 796.3.
3. Ramadan B Sopi, Mitko Mladenov, Icko Gjorgoski, Muharrem Jakupaj (2011). L-Citrulline Protects Against Hyperoxia-Induced Increase in Airway Contractile Responses FASEB J; 25: 864.2.
4. Mladenov M., Gjorgoski I.K., Dimovska J. Superoxide dismutase as a valuable marker of hyperthermic stress” – Euromedlab 2001 – 14th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory medicine. Book of abstracts, p 400.
5. Mladenov M., Gjorgoski I.K., Dimovska J. Role of glutathione peroxidase during the hiperthermic stress at rats treated with vitamin C” – World Chemistry Congress – Brisbane Australia 1-6 july 2001. Book of abstracts. p 143.
6. Mladenov M., Gjorgoski I.K and Dimovska J. The role of vitamin C in high temperature resistance at rats” 14th Balkan Congress of Clinical Chemistry and Laboratory Medicine – Ianina Greece 14-21 September 2001. Book of abstracts, p 68.
7. Mircevska V., Gjorgoski I.K., Mladenov M. Diagnostical mining of Tumor Necrosis Factor (TNF a) in the serum of patients with Multiplex sclerosis, Asthma bronchiale and Bronchitis obstructive” 3rd Balkan Congress of Immunology, Athens, Greece 3-8 June 2002. Book of abstracts p.144.