Д-р. Митко Младенов, редовен професор, е истакнат научник од областа на физиологијата, биофизиката и молекуларната биомедицина, со значајна меѓународна научна видливост и континуирана истражувачка продуктивност. Роден е на 17 февруари 1975 година во Ново Село, Струмица, каде го завршува основното образование, а средното образование го стекнува во СОУ „Јане Сандански“ во Струмица, природно-математичка насока, со континуиран одличен успех. Своето високо образование го продолжува на Институтот за биологија при Природно-математичкиот факултет во Скопје, каде дипломира во 1998 година на биохемиско-физиолошката насока, по што е ангажиран како стручен соработник на Заводот за физиологија и биохемија.
Магистерските студии ги завршува во 2004 година на истиот институт, по што е избран за асистент. Истата година реализира научно-истражувачки престој на Институтот за хемија и биохемија при Универзитетот „Ernst Moritz Arndt“ во Грајфсвалд, Германија, каде се насочува кон проучување на транспортните механизми на јони низ течно-течни интерфејси - истражувачка нишка што ќе ја одбележи неговата понатамошна научна кариера. Докторската дисертација ја изработува на Институтот за биофизика при Бугарската академија на науките во Софија, а ја брани во 2007 година, фокусирајќи се на сигналните механизми на грелинот во васкуларните мазни мускулни клетки.
По изборот во звањето доцент, во 2008 година престојува на постдокторски студии на Медицинскиот факултет при Универзитетот „Karls Ruprecht“ во Хајделберг, Германија, под менторство на проф. д-р Рудолф Шуберт, каде значително ги продлабочува своите истражувања во електрофизиологијата и клеточната биофизика. Овој престој претставува клучна точка во неговата интернационализација, воспоставувајќи долгорочни научни соработки со реномирани истражувачки групи, кои резултираат со бројни заеднички публикации во високо рангирани меѓународни списанија. Неговата континуирана научна мобилност се огледа и во редовните истражувачки престои во Хајделберг, како и во ангажманите како визитинг-професор на Универзитетот во Софија и на Медицинскиот универзитет во Москва.
Научниот опус на проф. Младенов опфаќа значителен број публикации во престижни меѓународни списанија, со фокус на јонски канали, механотрансдукција, клеточна сигнализација и патофизиолошки механизми на кардиоваскуларни и метаболни заболувања, што го позиционира како релевантен автор во современата биомедицинска наука. Учествувал во повеќе национални и меѓународни научноистражувачки проекти, а бил и раководител на меѓународни програми за академска размена, преку кои придонел за мобилност и научно усовршување на млади истражувачи. Добитник е на повеќе престижни грантови и стипендии, меѓу кои од FEBS, DFG и DAAD, како и од програмата Basileus, што дополнително ја потврдува неговата научна релевантност на европско ниво.
Активно учествува во научната заедница како потпретседател на Друштвото на физиолози на Македонија и член на Друштвото на биохемичари на Македонија. За своите научни достигнувања и придонес во развојот на природно-математичките науки, во 2015 година е прогласен за најдобар научник на Универзитетот „Св. Кирил и Методиј“ во Скопје.
Links
https://www.webofscience.com/wos/author/record/A-1980-2019
https://www.scopus.com/pages/citationOverview?authorsIds=15124496100&origin=AuthorNamesList
https://orcid.org/0000-0003-3475-2131
https://www.researchgate.net/profile/Mitko-Mladenov
https://scholar.google.com/citations?user=1LHuDw8AAAAJ&hl=en
Поглавја во монографии
Hadzy-Petrushev N, Angelovski M, Mladenov M. Advanced glycation end products and diabetes. in Obesity, Diabetes and Inflammation, 09/2023, pp. 99-128; doi:10.1007/978-3-031-39721-9, Springer.
Студиски престои
1. Sep 2019. Scholarship: senior research fellowship from Department of Fundamental and Applied Physiology, Russian National Research Medical University Moscow, Russian Federation. (еден месец)
2. Jun 2018. Scholarship: senior research fellowship from Department of Fundamental and Applied Physiology, Russian National Research Medical University Moscow, Russian Federation. (еден месец)
3. Aug 2017. Scholarship: senior research fellowship from Department of Fundamental and Applied Physiology, Russian National Research Medical University Moscow, Russian Federation. (еден месец)
4. Jun 2016. Scholarship: senior research fellowship from Department of Fundamental and Applied Physiology, Russian National Research Medical University Moscow, Russian Federation (два месеца)
5. Dec 2016. Scholarship: senior research fellowship from Faculty of Biology, Bucharest, Romania (две недели)
6. Jun 2015. Scholarship: senior research fellowship from Faculty of Clinical Medicine Mannheim, Karls Ruprecht University Heidelberg, Germany. (два месеца)
7. Oct 2014. Scholarship: senior research fellowship from Faculty of Clinical Medicine Mannheim, Karls Ruprecht University Heidelberg, Germany. (еден месец)
8. Sept 2014. Scholarship: senior research fellowship from Department of Fundamental and Applied Physiology, Russian National Research Medical University Moscow, Russian Federation. (еден месец)
9. Nov 2013. Staff exchange - BASILEUS IV – European exchange program. Grelin induced mesenteric artery contraction mediated by ciclooxigenases. (еден месец)
10. Apr 2013. Scholarship: senior research fellowship from Faculty of Clinical Medicine Mannheim, Karls Ruprecht University Heidelberg, Germany. Contribution of BKCa channels to arterial contraction-role of AMP-activated protein kinase. (четири месеца)
11. Jul 2011. Fellowship from FEBS - (Federation of European Biochemical Society). Kv Regulation by Shingosine Kinase 1 in Smooth Muscle Cells from Hamster a.gracilis. (два месеца)
12. Nov 2008. Scholarship: postdoctoral fellowship. Faculty for Clinical Medicine Mannheim, Karls Ruprecht University Heidelberg, Germany. (една година)
13. Jun 2008. Scholarship: student exchange fellowship from Czech Academy of Science. Institute for Molecular Neuro-endocrinology, Czech Academy of Science, Prague, Czech Republic. (еден месец)
14. Oct 2004. Scholarship: Fellowship from Alexander von Humboldt Germany. Institute of Chemistry and Biochemistry, Ernst Moritz Arndt University Greifswald, Germany. (два месеца)
Научни публикации во списанија со фактор на влијание
1. Sazdova IV, Gagov H, Hadzi-Petrushev N, Avtanski DB, Stojchevski R, Velichkovikj S, Konaktchieva M, Mladenov M. Advanced studies in molecular and metabolic mechanisms of diabetes: pathogenic crosstalk, biomarkers, and translational therapeutics. Applied Sciences. 2026. doi:10.3390/app16063027
2. Mitrokhin VM, Kamkin AG, Babkina II, Kamkina OV, Rodina AV, Zolotareva AV, Zolotarev VI, Mladenov M. Heart–brain axis in viral myocarditis: shared cytokine pathways, blood–brain barrier crosstalk, and neuroinflammatory consequences. Int J Mol Sci. 2026. doi:10.3390/ijms27062603
3. Sutanto E, Sutanto R, Velichkovikj S, Stojchevski R, Dragarska K, Mladenov M, Avtanski DB. AI-guided discovery of oncogenic signaling crosstalk in tumor progression and drug resistance. Oncol Res. 2026. doi:10.32604/or.2026.076157
4. Mishonova M, Koceva L, Pilicheva B, Sazdova IV, Hadzi-Petrushev N, Avtanski DB, Mladenov M. Indocyanine green as a marker for nose-to-brain delivery pathways, brain distribution, and PLGA nanoparticle efficiency. Int J Mol Sci. 2026. doi:10.3390/ijms27041782
5. Stojchevski R, Velichkovikj S, Bogdanov J, Avtanski DB, Sutanto E, Sutanto R, Dragarska K. Assessment of the anticancer and antimetastatic effects of monocarbonyl analogs of curcumin, C66 and B2BrBC, in breast cancer cells. Cancer Cell Int. 2026. doi:10.1186/s12935-026-04184-8
6. Budrowitz A, Mladenov M, Gagov H, Schubert R. Differential effect of pulsatile pressure on the myogenic responses of small arteries. Pflugers Arch Eur J Physiol. 2025. doi:10.1007/s00424-025-03145-w
7. Konaktchieva M, Stojchevski R, Hadzi-Petrushev N, Avtanski DB, Konakchieva R, Mladenov M. Curcumin and tetrahydrocurcumin as multi-organ modulators of the adipose tissue–gut–liver axis: mechanistic insights, therapeutic potential, and translational challenges. Pharmaceuticals. 2025. doi:10.3390/ph18121791
8. Zolotareva A, Zolotarev VI, Kamkina OV, Kamkin AG, Rodina AV, Bilichenko AS, Mladenov M. Hypergravity upregulates and simulated microgravity downregulates TRPM7 mechanosensitive ion channel expression in isolated rat cardiomyocytes. Bull Exp Biol Med. 2025. doi:10.1007/s10517-026-06572-6
9. Kamkin AG, Zolotarev V, Kamkina O, Rodina A, Zolotareva A, Bilichenko A, Mladenov M. Hypergravity enhances stretch sensitivity in rat cardiomyocytes via increased expression and activity of stretch-activated channels. Int J Mol Sci. 2025. doi:10.3390/ijms26199284
10. Kamkina OV, Rodina A, Kamkin A, Zolotareva A, Zolotarev V, Bilichenko A, Mladenov M. Mechanotransduction-driven modulation of L-type calcium channels: roles of nitric oxide, S-nitrosylation, and cGMP in rat ventricular cardiomyocytes. Int J Mol Sci. 2025. doi:10.3390/ijms26157539
11. Bilichenko AS, Zolotareva A, Kamkina OV, Kamkin AG, Rodina A, Zolotarev V, Mladenov M. Simulated microgravity attenuates the stretching sensitivity of mechanically gated channels in rat ventricular myocytes. Int J Mol Sci. 2025. doi:10.3390/ijms26146653
12. Konakchieva R, Mladenov M, Konaktchieva M, Georgiev GN, Hadzi-Petrushev N, Sazdova IV, Gagov H. Circadian clock deregulation and metabolic reprogramming: a systems biology approach to tissue-specific redox signaling and disease development. Int J Mol Sci. 2025. doi:10.3390/ijms26136267
13. Wang J, Jing K, Mitrokhin VM, Kamkin AG, Kamkina OV, Mladenov M. Crosstalk between MST1-Hippo and Wnt/β-catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology. J Physiol Biochem. 2025. doi:10.1007/s13105-025-01099-2
14. Singh SR, Bhaskar R, Ghosh S, Yarlagadda B, Singh KK, Verma P, Sengupta S, Mladenov M, Hadzi-Petrushev N, Stojchevski R, Sinha JK, Avtanski D. Exploring the genetic orchestra of cancer: the interplay between oncogenes and tumor-suppressor genes. Cancers. 2025 Mar 24;17(7):1082. doi:10.3390/cancers17071082.
15. Stojchevski R, Sutanto EA, Sutanto R, Hadzi-Petrushev N, Mladenov M, Singh SR, Sinha JK, Ghosh S, Yarlagadda B, Singh KK, Verma P, Sengupta S, Bhaskar R, Avtanski D. Translational advances in oncogene and tumor-suppressor gene research. Cancers. 2025 Mar 17;17(6):1008. doi:10.3390/cancers17061008.
16. Mladenov M, Sazdova I, Hadzi-Petrushev N, Konakchieva R, Gagov H. The role of reductive stress in the pathogenesis of endocrine-related metabolic diseases and cancer. Int J Mol Sci. 2025 Feb 23;26(5):1910. doi:10.3390/ijms26051910.
17. Hadzi-Petrushev N, Stojchevski R, Jakimovska A, Stamenkovska M, Josifovska S, Stamatoski A, Sazdova I, Sopi R, Kamkin A, Gagov H, Mladenov M, Avtanski D. GLUT5-overexpression-related tumorigenic implications. Mol Med. 2024 Aug 6;30(1):114. doi:10.1186/s10020-024-00879-8.
18. Stojchevski R, Velichkovikj S, Bogdanov J, Hadzi-Petrushev N, Mladenov M, Poretsky L, Avtanski D. Monocarbonyl analogs of curcumin C66 and B2BrBC modulate oxidative stress, JNK activity, and pancreatic gene expression in rats with streptozotocin-induced diabetes. Biochem Pharmacol. 2024 Nov;229:116491. doi:10.1016/j.bcp.2024.116491.
19. Stojchevski R, Chandrasekaran P, Hadzi-Petrushev N, Mladenov M, Avtanski D. Adipose tissue dysfunction related to climate change and air pollution: understanding the metabolic consequences. Int J Mol Sci. 2024 Jul 18;25(14):7849. doi:10.3390/ijms25147849.
20. Pyanova A, Serebryakov VN, Gagov H, Mladenov M, Schubert R. BK channels in tail artery vascular smooth muscle cells of normotensive (WKY) and hypertensive (SHR) rats possess similar calcium sensitivity but different responses to the vasodilator iloprost. Int J Mol Sci. 2024 Jun 28;25(13):7140. doi:10.3390/ijms25137140.
21. Mitrokhin V, Hadzi-Petrushev N, Kazanski V, Schileyko S, Kamkina O, Rodina A, Zolotareva A, Zolotarev V, Kamkin A, Mladenov M. The role of K(ACh) channels in atrial fibrillation. Cells. 2024 Jun 10;13(12):1014. doi:10.3390/cells13121014.
22. Sazdova I, Hadzi-Petrushev N, Keremidarska-Markova M, Stojchevski R, Sopi R, Shileiko S, Mitrokhin V, Gagov H, Avtanski D, Lubomirov LT, Mladenov M. SIRT-associated attenuation of cellular senescence in vascular wall. Mech Ageing Dev. 2024, May 17;220:111943. doi: 10.1016/j.mad.2024.111943.
23. Avtanski D, Hadzi-Petrushev N, Josifovska S, Mladenov M, Reddy V. Emerging technologies in adipose tissue research. Adipocyte. 2023 Dec;12(1):2248673. doi:10.1080/21623945. 2023. 2248673.
24. Josifovska S, Panov S, Hadzi-Petrushev N, Mitrokhin V, Kamkin A, Stojchevski R, Avtanski D, Mladenov M. Positive tetrahydrocurcumin-associated brain-related metabolomic implications. Molecules. 2023, Apr 26;28(9):3734. doi: 10.3390/molecules28093734.
25. Mladenov M, Lubomirov L, Grisk O, Avtanski D, Mitrokhin V, Sazdova I, Keremidarska-Markova M, Danailova Y, Nikolaev G, Konakchieva R, Gagov H. Oxidative stress, reductive stress and antioxidants in vascular pathogenesis and aging. Antioxidants (Basel). 2023, May 19;12(5):1126. doi: 10.3390/antiox12051126.
26. Kamkin AG, Kamkina OV, Kazansky VE, Mitrokhin VM, Bilichenko A, Nasedkina EA, Shileiko SA, Rodina AS, Zolotareva AD, Zolotarev VI, Sutyagin PV, Mladenov M. Identification of RNA reads encoding different channels in isolated rat ventricular myocytes and the effect of cell stretching on L-type Ca2+ current. Biol Direct. 2023, Oct 30;18(1):70. doi: 10.1186/s13062-023-00427-0.
27. Här K, Lysenko NN, Dimitrova D, Schlüter T, Zavaritskaya O, Kamkin AG, Mladenov M, Grisk O, Köhler R, Gagov H, Schubert R. Kv2.1 channels prevent vasomotion and safeguard myogenic reactivity in rat small superior cerebellar arteries. Cells. 2023, Aug 2;12(15):1989. doi: 10.3390/cells12151989.
28. Sazdova I, Keremidarska-Markova M, Dimitrova D, Mitrokhin V, Kamkin A, Hadzi-Petrushev N, Bogdanov J, Schubert R, Gagov H, Avtanski D, Mladenov M. Anticarcinogenic potency of EF24: An overview of its pharmacokinetics, efficacy, mechanism of action, and nanoformulation for drug delivery. Cancers (Basel). 2023, Nov 20;15(22):5478. doi: 10.3390/cancers15225478.
29. Angelovski M, Hadzi-Petrushev N, Mitrokhin V, Kamkin A, Mladenov M. Myocardial infarction and oxidative damage in animal models: objective and expectations from the application of cysteine derivatives. Toxicol Mech Methods. 2023; May 10:1-17. doi: 10.1080/15376516.2022.2069530.
30. Mladenov M, Bogdanov J, Bogdanov B, Hadzi-Petrushev N, Kamkin A, Stojchevski R, Avtanski D. Efficacy of the monocarbonyl analog of curcumin C66 in the reduction of cardiovascular and kidney complications. Mol Med. 2022, Oct 31;28(1):129. doi: 10.1186/s10020-022-00559-5.
31. Zhang L, Li C, Wang S, Avtanski D, Hadzi-Petrushev N, Mitrokhin V, Mladenov M, Wang F. Tetrahydrocurcumin-related vascular protection: An overview of the findings from animal disease models. Molecules. 2022;27(16):5100. doi: 10.3390/molecules 27165100.
32. Zavaritskaya O, Dudem S, Ma D, Rabab KE, Albrecht S, Tsvetkov D, Kassmann M, Thornbury K, Mladenov M, Kammermeier C, Sergeant G, Mullins N, Wouappi O, Wurm H, Kannt A, Gollasch M, Hollywood MA, Schubert R. Vasodilation of rat skeletal muscle arteries by the novel BK channel opener GoSlo is mediated by the simultaneous activation of BK and Kv7 channels. Br J Pharmacol. 2020;177(5):1164-1186. doi: 10.1111/bph.14910.
33. Mitrokhin V, Filatova TS, Shim A, Bilichenko A, Abramochkin DV, Kamkin A, Mladenov M: Involvement of L-type Ca2+ channels in IFN-γ- induced signaling in rat ventricular cardiomyocytes. J Physiol Biochem. 02/2019;75:109-115. doi:10.1007/s13105-019-00662-y.
34. Hadzi-Petrushev N, Dimovska K, Jankulovski N, Mitrov D, Mladenov M. Supplementation with alpha-tocopherol and ascorbic acid to statin therapy for men with nonalcoholic fatty liver disease. Adv Pharmacol Sci. 05/2018; 2018(6). doi:10.1155/2018/4673061.
35. Schmid J, Müller B, Heppeler D, Gaynullina D, Kassmann M, Gagov H, Mladenov M, Gollasch M, Schubert R. The unexpected role of calcium-activated potassium channels: Limitation of nitric oxide-induced arterial relaxation. J Am Heart Assoc. 02/2018; 7(7). doi:10.1161/JAHA.117.007808.
36. Hadzi-Petrushev N, Bogdanov J, Krajoska J, Ilievska J, Bogdanova-Popov B, Gjorgievska E, Mitrokhin V, Sopi R, Gagov H, Kamkin A, Mladenov M. Comparative study of the antioxidant properties of monocarbonyl curcumin analogues C66 and B2BrBC in isoproteranol induced cardiac damage. Life Sci. 01/2018; 197. doi:10.1016/j.lfs.2018.01.028
37. Mitrokhin V, Nikitin A, Brovkina O, Khodyrev D, Zotov A, Vakhrushev N, Dragunov D, Shim A, Mladenov M, Kamkin A. Association between IL-18/18R gene polymorphisms and coronary artery disease: Influence of IL-18/18R genetic variants on cytokine expression. J Inflamm Res. 01/2018;11:1-9. doi:10.2147/JIR.S153370.
38. Mitrokhin V, Nikitin A, Brovkina O, Khodyrev D, Zotov A, Vachrushev N, Dragunov D, Shim A, Mladenov M, Kamkin A. Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: Influence of interleukin-6/6R gene polymorphisms on inflammatory markers. J Inflamm Res. 10/2017; 10:1-10. doi:10.2147/JIR.S141682.
39. Mitrokhin V, Kazanski V, Kalsin V, Mladenov M, Kamkin A. Interleukin-6 induced activation of a non-selective outward cation conductance in human cardiac fibroblasts. Cytokine. 09/2017; 97:117-122. doi:10.1016/j.cyto.2017.06.004.
40. Vela D, Lesoski J, Vela Z, Jakupaj M, Mladenov M, Sopi R. Insulin treatment corrects hepcidin but not YKL-40 levels in persons with type 2 diabetes mellitus matched by Body Mass Index, Waist-to-Height Ratio, C-Reactive protein and Creatinine. BMC Endocr Disord. 08/2017; 17(1). doi:10.1186/s12902-017-0204-4.
41. Mitrokhin V, Shim A, Aksyonov A, Zotov A, Konev A, Ovchinnikov R, Mladenov M, Kamkin A. Circulating interleukin-18: Association with IL-8, IL-10 and VEGF serum levels in patients with and without heart rhythm disorders. Int J Cardiol. 07/2016; 215:105-109.
42. Gabrić D, Blašković M, Gjorgievska E, Mladenov M, Tašič B, Juric I, Ban T. Evaluation of bone healing after osteotomies prepared with Er:YAG laser in contact and noncontact modes and piezosurgery-an animal study. J Oral Maxillofac Surg. 09/2015;74(1). doi:10.1016/j.joms.2015.08.017.
43. Mitrokhin V, Mladenov M, Kamkin A. Effects of interleukin-6 on the bio-electric activity of rat atrial tissue under normal conditions and during gradual stretching. Immunobiology. 05/2015; 220(9). doi:10.1016/j.imbio.2015.05.003.
44. Hadzi-Petrushev N, Mladenov K, Sopi R, Stojkovski V, Mitrov D, Ilieski V, Mladenov M. Enhanced lipid peroxidation and inflammation during heat exposure in rats of different ages: Role of α-tocopherol. J Therm Biol. 08/2013;38(8):474-479. doi:10.1016/j.jtherbio. 2013.08.005.
45. Zavaritskaya O, Zhuravleva N, Schleifenbaum J, Gloe T, Devermann L, Kluge R, Mladenov M, Frey M, Gagov H, Fésüs G, Gollasch M, Schubert R: Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction. Hypertension. 11/2012;61(1). doi:10.1161/HYPERTENSIONAHA.112.197566.
46. Sopi R, Zaidi S, Mladenov M, Sahiti H, Istrefi Z, Gjorgoski I, Lajçi A, Jakupaj M. L-citrulline supplementation reverses the impaired airway relaxation in neonatal rats exposed to hyperoxia. Respir Res. 08/2012;13(1):68. doi:10.1186/1465-9921-13-68.
47. Leuner K, Heiser JH, Derksen S, Mladenov MI, Fehske SJ, Schubert R, Gollasch M, Schneider G, Harteneck C, Chatterjee SS, Müller WF. Simple 2,4-Diacylphloroglucinols as classic transient receptor potential-6 activators-identification of a novel pharmacophore. Mol Pharmacol. 12/2009; 77(3):368-77. doi:10.1124/mol.109.057513.
48. Quentel F, Mirceski V, L'Her M, Mladenov M, Scholz F, Elleouet C. Comparative study of the thermodynamics and kinetics of the ion transfer across the liquid|liquid interface by means of three-phase electrodes. J Phys Chem B. 08/2005;109(27-27):13228-13236. doi:10.1021/jp0519969.
49. Keremidarska-Markova M, Sazdova I, Mladenov M, Pilicheva B, Zagorchev P, Gagov H. Sirtuin 1 and hormonal regulations in aging. Appl Sci. 2024;14:12051. doi:10.3390/app142412051.
50. Reçica R, Kryeziu I, Thaçi Q, Avtanski D, Mladenov M, Basholli-Salihu M, Sopi R. Protective effects of resveratrol against airway hyperreactivity, oxidative stress, and lung inflammation in a rat pup model of bronchopulmonary dysplasia. Physiol Res. 2024, Apr 30;73(2):239-251. doi: 10.33549/physiolres.935239.
51. Mitrokhin V, Bilichenko A, Kazanski V, Schobik R, Shileiko S, Revkova V, Kalsin V, Kamkina O, Kamkin A, Mladenov M. Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts. Exp Biol Med. 2023, Dec;248(23):2341-2350. doi:10.1177/15353702 231218488.
52. Kryeziu I, Reçica S, Thaçi Q, Kurshumliu F, Hadzi-Petrushev N, Basholli-Salihu M, Mladenov M, Sopi RB. Quercetin supplementation attenuates airway hyperreactivity and restores airway relaxation in rat pups exposed to hyperoxia. Exp Biol Med. 2023, Sep;248(17):1492-1499. doi: 10.1177/15353702231199468.
53. Avtanski D, Reddy V, Stojchevski R, Hadzi-Petrushev N, Mladenov M. The microbiome in the obesity-breast cancer axis: diagnostic and therapeutic potential. Pathogens. 2023, Nov 29;12(12):1402. doi: 10.3390/pathogens12121402.
54. Angelovski M, Hadzi-Petrushev N, Mitrokhin V, Kamkin A, Mladenov M. Myocardial infarction and oxidative damage in animal models: objective and expectations from the application of cysteine derivatives. Toxicol Mech Methods. 2023; May 10:1-17. doi: 10.1080/15376516.2022.2069530.
55. Angelovski M, Hadzi-Petrushev N, Atanasov D, Nikodinovski A, Mitrokhin V, Avtanski BD, and Mladenov M. Protective effects of L-2-Oxothiazolidine-4-carboxylate during isoproterenol-induced myocardial infarction in rats: in vivo study. Life. 2022, 12, 1466. https://doi.org/10.3390/life12101466.
56. Sazdova I, Keremidarska-Markova M, Chichova M, Uzunov B, Nikolaev G, Mladenov M, Schubert R, Stoyneva-Gärtner M, Gagov HS. Review of cyanotoxicity studies based on cell cultures. J Toxicol. 2022;5647178. doi: 10.1155/2022/5647178.
57. Kamkin GA, Kamkina VO, Shim LA, Bilichenko A, Mitrokhin MV, Kazansky EV, Filatova ST, Abramochkin VD, Mladenov IM. The role of activation of two different sGC binding sites by NO‐dependent and NO‐independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes. Physiol Rep. 2022;10:e15246. https://doi.org/10.14814/phy2. 15246.
58. Atanasova-Panchevska N, Stojchevski R, Hadzi-Petrushev N, Mitrokhin V, Avtanski D, Mladenov M. Antibacterial and antiviral properties of tetrahydrocurcumin-based formulations: An overview of their metabolism in different microbiotic compartments. Life (Basel). 2022, Oct 26;12(11):1708. doi: 10.3390/life12111708.
59. Mitrokhin V, Gorbacheva L, Vachrushev N, Hadzi-Petrushev N, Kamkin A, Mladenov M. Cardiomyocytes' prolonged IL-2 incubation induces enhancement in L-type Ca2+ channels mediated by inhibitory-kappaB kinase/nuclear factor-kappaB signalling. Basic Clin Pharmacol Toxicol. 2021;128(2):234-240. doi: 10.1111/bcpt.13491.
60. Gabrić D, Aumiler D, Vuletić M, Gjorgievska E, Blašković M, Mladenov M, Pavlić V. Thermal evaluation by infrared thermography measurement of osteotomies performed with Er:YAG laser, piezosurgery and surgical drill - an animal study. Materials. 2021 Jun 3;14(11):3051. doi: 10.3390/ma14113051.
61. Thaçi Q, Reçica S, Kryeziu I, Mitrokhin V, Kamkin A, Sopi R, Hadzi-Petrushev N, Mladenov M. VIP/PACAP signaling as an alternative target during hyperoxic exposure in preterm newborns. Physiol Res. 2021;70(4):489-499. doi: 10.33549/ physiolres.934638.
62. Ma D, Gaynullina D, Schmidt N, Mladenov M, Schubert R. The functional availability of arterial Kv7 channels is suppressed sonsiderably by Large-conductance calcium-activated potassium channels in 2- to 3-month old but not in 10- to 15-day old rats. Front Physiol. 2020;11:597395. doi: 10.3389/fphys.2020.597395.
63. Stamenkovska M, Thaçi Q, Hadzi-Petrushev N, Angelovski M, Bogdanov J, Reçica S, Kryeziu I, Gagov H, Mitrokhin V, Kamkin A, Schubert R, Mladenov M, Sopi RB. Curcumin analogs (B2BrBC and C66) supplementation attenuates airway hyperreactivity and promote airway relaxation in neonatal rats exposed to hyperoxia. Physiol Rep. 2020;8(16):e14555. doi: 10.14814/phy2.14555.
64. Mitrokhin V, Kalsin V, Kamkina O, Babkina I, Zotov A, Troitskiy VA, Mladenov M, Kamkin A. Participation of PKG and PKA-related pathways in the IFN-γ induced modulation of the BKCa channel activity in human cardiac fibroblasts. J Pharmacol Sci. 2019;141(1):25-31. doi: 10.1016/j.jphs.2019.08.006.
65. Filatova T, Mitrokhin V, Kamkina O, Lovchikova I, Mladenov M, Kamkin A: Long-term incubation of IL-2 activates L-type calcium channels in rat ventricle cardiomyocytes. Cardiovasc Toxicol. 03/2019; 19(1):48-55. doi:10.1007/s12012-018-9472-0.
66. Mitrokhin V, Gorbacheva L, Mladenov M, Kamkin A: IL-2-induced NF-κB phosphorylation upregulates cation nonselective conductance in human cardiac fibroblasts. Int Immunopharmacol. 09/2018;64:170-174. doi:10.1016/j.intimp.2018.08.040.
67. Gagov H, Chichova M, Mladenov M. Endolymph composition: Paradigm or inevitability. Physiol Res. 05/2018; 67(2):175-179.
68. Vela D, Sopi R, Mladenov M. Low hepcidin in Diabetes mellitus: Examining the molecular links and their clinical implications. Can J Diabetes. 04/2017;42(2)., doi:10.1016/j.jcjd.2017.04.007.
69. Kazanski V, Mitrokhin V, Mladenov M, Kamkin A. Cytokine effects on mechano-induced electrical activity in atrial myocardium. Immunol Invest. 01/2017;46(1)., doi:10.1080/08820139.2016.1208220.
70. Shim A, Aksyonov A, Mitrokhin V, Lovchikova I, Konoplyannikov M, Konev A, Zotov A, Ovchinnikov R, Antova E, Mladenov M, Kamkin A. Serum interleukin-6: Association with circulating cytokine serum levels in patients with sinus arrhythmia and patients with coronary artery disease. Cell Immunol. 12/2016;310:178-183. doi:10.1016/j.cellimm.2016.09.007.
71. Emilova R, Dimitrova D, Mladenov M, Hadzi-Petrushev N, Daneva T, Padeshki P, Schubert R, Chichova M, Lubomirov L, Simeonovska-Nikolova D, Gagov H. Diabetes converts arterial regulation by perivascular adipose tissue from relaxation into H2O2-mediated contraction. Physiol Res. 01/2016; 65(5):799-807.
72. Mladenov M, Gokik M, Hadzi-Petrushev N, Gjorgoski I, Jankulovski N. The relationship between antioxidant enzymes and lipid peroxidation in senescent rat erythrocytes. Physiol Res. 12/2015; 64(6):893-896.
73. Mitrokhin V, Mladenov M, Kamkin A. IL-1 provokes electrical abnormalities in rat atrial myocardium. Int Immunopharmacol. 10/2015; 28:780-784. doi:10.1016/j.intimp.2015. 08.006.
74. Ovchinnikov R, Mitrokhin V, Mladenov M. Effects of Interleukin-17A on the bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching. Cytokine. 07/2015;76(2). doi:10.1016/j.cyto.2015.06.016.
75. Aksyonov A, Mitrokhin V, Mladenov M. Effects of interleukin-2 on bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching. Immunol Lett. 06/2015; 167(1). doi:10.1016/j.imlet.2015.06.009.
76. Hadzy-Petrushev N, Stojkovski V, Mitrov D, Mladenov M. D-Galactose induced changes in enzymatic antioxidant status in rats of different ages. Physiol Res. 01/2015; 64(1).
77. Hadzi-Petrushev N, Stojkovski V, Mitrov D, Mladenov M. D-galactose induced inflammation lipid peroxidation and platelet activation in rats. Cytokine. 06/2014;69(1). doi:10.1016/j.cyto.2014.05.006.
78. Stojkovski V, Hadzi-Petrushev N, Ilievski V, Sopi R, Gjorgoski I, Mitrov D, Jankulovski N, Mladenov M. Age and heat exposure-dependent changes in antioxidant enzymes activities in rat's liver and brain mitochondria: Role of α-tocopherol. Physiol Res. 09/2013; 62(5).
79. Hadzi-Petrushev N, Jankulovski N, Milev M, Filipovska P, Gagov H, Gjorgievska E, Mitrov D, Sopi R, Hristov K, Mladenov M: L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent peroxidation in rat's liver and kidney. J Therm Biol. 08/2012; 37(5-5):361-365. doi:10.1016/j.jtherbio.2011.12.013.
80. Dimitrova D, Dimitrov S, Iliev I, Mladenov M, Hristov K, Mihov D, Duridanova D, Gagov H. Ghrelin signaling in human mesenteric arteries. J Physiol Pharmacol. 08/2010; 61(4):383-90.
81. Mladenov M, Tanska V, Vitkovska T, Gjorgoski I, Dinevska-Kofkarovska S, Stafilov S, Hristov K, Duridanova D. Evidence for the influence of vitamin C on age- and heat exposure-dependent deterioration of biochemical function in rat's liver and kidney. J Therm Biol. 12/2008; 33(8):431-436. doi:10.1016/j.jtherbio.2008.07.001.
82. Mladenov M, Hristov K, Dimitrova D, Schubert R, Lubomirov L, Gjorgoski I, Duridanova D, Gagov H. Ghrelin signaling in guinea-pig femoral artery smooth muscle cells. Acta Physiol. (Oxf). 08/2008;194(3):195-206. doi:10.1111/j.1748-1716.2008.01880.x
83. Mladenov M, Gjorgoski I, Stafilov T, Duridanova D. The effect of vitamin C on the content of lipid hydroperoxides and carbonyl groups in rat plasma varies with age and acute heat exposure. J Therm Biol. 12/2006;31(8):588-593. doi:10.1016/j.jtherbio.2006.08.001.
84. Mladenov M, Mirceski V, Gjorgoski I, Jordanoski B. Redox kinetic measurements of glutathione at the mercury electrode by means of square-wave voltammetry. The role of copper, cadmium and zinc ions. Bioelectrochemistry. 01/2005;65(1):69-76. doi:10.1016/j.bioelechem.2004.05.007.
85. Stojchevski R, Velichkovikj S, Bogdanov J, Hadzi-Petrushev N, Mladenov M, Poretsky L, Avtanski D. Impact of monocarbonyl analogs of curcumin (MACs) C66 and B2BrBC on the expression of diabetes-associated genes in streptozotocin-treated rat pancreatic RIN-m cells-quantitative RT-PCR array data. Data Brief. 2024 Sep 16;57:110952. doi:10.1016/j.dib.2024.110952.
86. Mitrokhin VM, Kamkina OV, Kamkin AG, Rodina AS, Zolotareva AD, Zolotarev VI, Kazansky VE, Gorbacheva LR, Bilichenko AS, Shileiko SA, Mladenov M. Simulated microgravity and hypergravity affect the expression level of soluble guanylate cyclase, adenylate cyclase, and phosphodiesterase genes in rat ventricular cardiomyocytes. Bull Exp Biol Med. 2024, Jan;176(3):359-362. doi: 10.1007/s10517-024-06024-z.
87. Angelovski M, Spirovska M, Nikodinovski A, Stamatoski A, Atanasov D, Mladenov M, Hadzi-Petrushev N. Serum redox markers in uncomplicated type 2 diabetes mellitus accompanied with abnormal iron levels. Cent Eur J Public Health. 2023, Jun;31(2):133-139. doi: 10.21101/cejph. a7399.
88. Kamkin AG, Mitrokhin VM, Kamkina OV, Kazansky VE, Bilichenko AS, Rodina AS, Zolotareva AD, Zolotarev VI, Sutyagin PV, Mladenov MI. Hypergravity increases the number of gene transcripts of mechanically gated and mechanosensitive ion channels in rat ventricular cardiomyocytes. Bull Exp Biol Med. 2023 Oct;175(6):730-733. doi: 10.1007/s10517-023-05955-3.
89. Hadzi-Petrushev N, Angelovski M, Rebok K, Mitrokhin V, Kamkin A, Mladenov M. Antioxidant and anti-inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline-induced right ventricular hypertrophy. J Biochem Mol Toxicol. 2019;33(8):e22353. doi: 10.1002/jbt.22353.
90. Hadzi-Petrushev N, Gjorgievska E, Gabrić D, Dinescu S, Mitrokhin V, Mladenov M. Circulatory leukotriene changes during bone healing following osteotomies prepared with Er:YAG laser and piezosurgery: An animal study. Biotechnol Biotechnol Equip. 02/2019; doi:10.1080/13102818.2019. 1577171.
91. Filatova TS, Mitrokhin V, Kazanski V, Mladenov M, Kamkin A. The microtubule network serves as a basic target in stretch-induced activation of mechano-gated channels in rat ventricular cardiomyocytes. World Heart J. 07/2018; 10(2):1-9.
92. Mitrokhin V, Mladenov M, Gorbacheva LR, Babkina I, Lovchikova I, Kazanski V, Kamkin A. Influence of NO and [Ca2+]o on [Ca2+]i homeostasis in rat ventricular cardiomyocytes. Biotechnol Biotechnol Equip. 07/2018;32(5):1338-1343. doi:10.1080/13102818.2018. 1488621.
93. Antova E, Petkovska L, Bosevski M, Stojkovik J, Hadzy-Petrushev N, Kamkin A, Mladenov M. Nt-ProBNP Discriminatory role between symptomatic and asymptomatic patients with severe valvular aortic stenosis. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 07/2018; 39(1):15-28., doi:10.2478/prilozi-2018-0020.
94. Shim A, Mitrokhin V, Kazanski V, Mladenov M, and Kamkin A. Discrete stretching eliminates electrophysiological dose-dependent effects of the nitric oxide donor SNAP in the rat atrium. Bull Exp Biol Med. 10/2017; 163(6):705-709. doi:10.1007/s10517-017-3885-9.
95. Shim A, Mitrokhin V, Gorbacheva L, Savinkova I, Pustovit K, Mladenov M, Kamkin A. Kinetics of mechanical stretch-induced nitric oxide production in rat ventricular cardiac myocytes. Bull Exp Biol Med. 09/2017;163/5:532-535. doi:10.1007/s10517-017-3853-4.
96. Hadzi-Petrushev N, Mitrov D, Kostovski V, Mladenov M. The impact of Vitamin C on the relationship among inflammation, lipid peroxidation and platelet activation during analgesic nephropathy in rats. J Basic Clin Physiol Pharmacol. 08/2017;28(5). doi:10.1515/jbcpp-2016-0150.
97. Vela D, Leshoski J, Gjorgievska E, Hadzi-Petrushev N, Jakupaj M, Sopi R, Mladenov M. The role of insulin therapy in correcting hepcidin levels in patients with type 2 Diabetes mellitus. Oman Med J. 01/2017; 32(3):195-200. doi:10.5001/omj.2017.37.
98. Blaskovic M, Gabrić D, Coleman NJ, Slipper IJ, Mladenov M, Gjorgievska E. Bone healing following different types of osteotomy. Scanning electron microscopy (SEM) and three-dimensional SEM analyses. Microsc Microanal. 12/2016;22(06):1170-1178. doi:10.1017/S1431927616011971.
99. Stephanova D, Daskalova M, Mladenov M. Internodal action potentials and their current kinetics in simulated chronic inflammatory demyelinating polyneuropathy at 20°C–42°C. C.R. Acad. Bul. Sci. 01/2016; 69(1):99-104.
100. Ovchinnikov R, Mitrokhin V, Mladenov M. Effects of vascular endothelial growth factor-b on the bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching. J Biol Regul Homeost Agents.12/2015; 29(4):835-840.
101. Stephanova D, M. Daskalova M, M. Mladenov M. Conducting processes in simulated chronic inflammatory demyelinating polyneuropathy at 20°C–42°C. J Integr Neurosci. 01/2015; 14(01). doi:10.1142/S0219635215500065.
102. Mitrov D, Hadzi-Petrushev N, Stojkovski V, Gjorgievska E, Gagov H, Mladenov M. Influence of chronic chromium exposure on lipid peroxidation, inflammation, and platelet activation processes in rats. J Biol Regul Homeost Agents. 07/2014; 28(3):531-5.
103. Gjorgievska SE, Nicholson JW, Apostolska SM, Coleman NJ, Booth SE, Slipper IJ, Mladenov MI. Interfacial Properties of Three Different Bioactive Dentine Substitutes. Microsc Microanal. 2013;19(6):1450-1457. doi: 10.1017/S1431927613013573.
104. Hadzi-Petrushev N, Jankulovski N, Hristov K, Mladenov M. L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat's blood plasma. J Physiol Sci. 07/2011; 61(5):437-42. doi:10.1007/s12576-011-0165-8.
105. Mladenov M, Hristov K, Duridanova D. Ghrelin suppresses potassium currents in smooth muscle cells of the human mesenteric artery. Gen Physiol Biophys. 10/2006;25(3):333-338.
106. Kamkin AG, Mitrokhin VM, Kamkina OV, Kazansky VE, Rodina AS, Zolotareva AD, Zolotarev VI, Sutyagin PV, Mladenov MI, Shenkman BS, Kalashnikov VE, Orlov OI. Simulated microgravity changes the number of mechanically gated and mechanosensitive ion channels genes transcripts in rat ventricular cardiomyocytes. Dokl Biochem Biophys. 2023 Oct;512(1):251-255. doi: 10.1134/S1607672923700369.
107. Dinescu S, Ignat S, Predoiu L, Hermenean A, Ionita M, Mladenov M, Costache M. Graphene oxide improves chitosan-based biomaterials with applications in bone tissue engineering. Rom Biotechnol Lett. 06/2017;22(6):13108-13115.
108. Emilova R, Dimitrova D, Mladenov M, Daneva T, Schubert R, Gagov H. Cystathionine gamma-lyase in perivascular adipose tissue has a reversed regulatory effect in the arteries of diabetic rats. Biotechnol Biotechnol Equip. 01/2015. doi:10.1080/13102818. 2014.991565.
Презентирање научни резултати на конгреси и симпозиуми
1. Stojchevski, R.; Sutanto, E.; Dragarska, K.; Avtanski, D.B.; et al. Drug-like ADME Profiles and Antimetastatic Properties of Monocarbonyl Curcumin Analogs C66 and B2BrBC with Improved Stability. J. Endocr. Soc. 2025.
2. Stojchevski R, Sutanto E, Dragarska K, Todorovska I, Hadzi-Petrushev N, Bogdanov J, Mladenov M, Poretsky L, Avtanski D. Drug-like ADME Profiles and Antimetastatic Properties of Monocarbonyl Curcumin Analogs C66 and B2BrBC with Improved Stability. ENDO 2025, July 12–15, 2025, San Francisco, California.
3. Stojchevski R, Bogdanov J, Hadzi-Petrushev N, Mladenov M, Poretsky L, Avtanski D. Monocarbonyl analogs of curcumin C66 and B2BrBC modulate diabetes-related gene expression in rat pancreatic cells. Diabetes 73(Supplement_1), 06/2024. doi:10.2337/db24-1772-P.
4. Stojchevski R, Lavi AB, Bogdanov J, Hadzi-Petrushev N, Mladenov M, Poretsky L, Avtanski D. Impact of the monocarbonyl analogs of curcumin, C66 and B2BrBC, on the protein expression of epithelial and mesenchymal markers in MCF-7 breast cancer cells. Journal of the Endocrine Society 8(Supplement_1), 10/2024. doi:10.1210/jendso/bvae163.2256
5. Stojchevski R, Hadzy-Petrushev N, Mladenov M, Bogdanov J, Velichkovik S, Poretsky L, Avtanski D. Effects of two experimental monocarbonyl analogs of curcumin (MACs) on breast cancer growth, migration, and epithelial-to-mesenchymal transition (EMT), Journal of Endocrine Society 7(Supplement_1), 09/2023, doi:10.1210/jendso/bvad114.2183
6. Todorovska I, Dragarska K, Hadzy-Petrushev N, Bogdanov J, Mladenov M. Investigating the structural features of some monocarbonyl curcuminoids: insights into their pharmacological profile. 26th Congress of SCTM, Ohrid, N. Macedonia, 09/2023. doi:10.13140/RG.2.2.24086.93761#mce_temp_url#
7. Dragarska K, Todorovska I, Stojchevski R, Hadzy-Petrushev N, Mladenov M, Avtanski D, Bogdanov J. Design and in vitro evaluation of monocarbonyl curcumin analogs eliciting breast cancer cytotoxicity. 26th Congress of SCTM, Ohrid, N. Macedonia, 09/2023. doi:10.13140/RG.2.2.17376.05124
8. Stojchevski R, Angelovski M, Velichkovikj S, Hadzy-Petrushev N, Bogdanov J, Mladenov M, Poretsky L, Avtanski D. Monocarbonyl curcumin analogs C66 and B2BrBC improve redox status in streptozotocin-induced diabetic rats. Diabetes, 72(Supplement_1). 06/2023. doi:10.2337/db23-1807-PUB
9. Thaçi Q, Kryeziu I, Recica S, Beqiraj- Zeqiraj Q, Bislimi K, Mladenov M, Sopi B.R. Pituitary adenylate cyclase activating peptide restores hyperoxia-impaired relaxation of tracheal smooth muscle in neonatal rats. Physiology, 38(S1), 05/2023. doi: 10.1152/physiol.2023. 38.S1.5796245
10. Sopi B.R, Recica S, Kryeziu I, Basholli-Salihu M, Orqusha N, Mladenov M, Neziri B, Thaçi Q. Vasoactive intestinal peptide reverses the impaired airway relaxation in neonatal rats exposed to hyperoxia. Physiology, 38(S1), 05/2023. doi:10.1152/physiol.2023.38. S1.5796233
11. Stojchevski R, Angelovski M, Velichkovikj S, Hadzy-Petrushev N, Mladenov M, Bogdanov J, Poretsky L, Avtanski D. Effect of monocarbonyl curcumin analogues C66 and B2BrBC on pancreatic expression of genes related to insulin signaling pathway and oxidative stress in streptozotocin-induced diabetes. Diabetes, 71(Supplement_1), 06/2022. doi:10.2337/ db22-557-P
12. Angelovski M, Atanasov D, Mladenov M, Hadzy-Petrushev N. Effects of L-2-Oxothiazolidine-4-carboxylate on isoproterenol-induced acute myocardial infarction in rats. 7th Congress of Pharmacy in R. Macedonia, Mac. Pharm. Bull. 66 (Suppl_1). 2020. http://bulletin.mfd.org.mk/volume-66-supp-1
13. Hadzy-Petrushev N, Angelovski M, Nestoroska D, Gjorgoski I, Rebok K, Mitrokhin V, Kamkin A, Mladenov M. Protective effects of the monocarbonyl curcumin analogues B2BRBC and C66 in monocrotaline-induced right ventricular hypertrophy. Kliment’s Days, 11/2018. Sofia Bulgaria. doi:10.13140/RG.2.2.35821.64485
14. Gabric D, Gjorgievska E, Blaskovic M, Mladenov M, Filipovic-Zore I, Aumiler D: Thermal evaluation by infrared measurement of osteotomies performed with Er:YAG laser, piezosurgery–an animal study. Clin Oral Impl Res. 2017; 28(Suppl. 13).
15. Islam Kryeziu, Qëndrim Thaçi, Shkëlzen Reçica, Fisnik Kurshumliu, Driton Vela, Mitko Mladenov, Mimoza Basholli, Ramadan B Sopi: Quercetin Reverses the Enhanced Contractile Responses of Tracheal Smooth Muscle of Neonatal Rats Exposed to Hyperoxia. Experimental Biology 2017 (American Physiological Society), Chicago, USA - Scientific Sessions; 04/2017.
16. Gabric D, Hadzi-Petrushev N, Gjorgievska E, Costache M, Pelivan I, Mladenov M: Circulatory leukotriene changes during bone healing following Er:YAG laser and piezosurgery osteotomies - an animal study Clin Oral Impl Res. 2017; 28(Suppl. 14).
17. Gabric D, Blaskovic M, Smojver I, Coleman NJ, Slipper IJ, Mladenov M, Vrdoljak DV, Gjorgievska E: Evaluation of bone healing following different types of osteotomy using SEM and 3D-SEM analyses – an animal study. Clin. Oral Impl. Res, 09/2016
18. Ramadan B Sopi, Burim Neziri, Mitko Mladenov, Driton Vela, Njomza Lajçi, Qëndrim Thaçi, Kemajl Bislimi, Muharrem Jakupaj, Azem Lajçi: EP1 Receptor Agonists Augment Hyperoxia-Induced Airway Hyperresponsiveness. Experimental Biology 2016 (American Physiological Society), San Diego - Scientific Sessions 04/2016.
19. Gabric D, Blaskovic M, Gjorgievska E, Mladenov M, Bago-Juric I, T Ban T: Evaluation of bone healing after osteotomies prepared with Er:YAG laser and piezosurgery using laser profilometry – an animal study. Clin. Oral Impl. Res. 26 (Suppl. 12), 12/2015
20. Muharrem Jakupaj, Ramadan B Sopi, Ismail Dreshaj, Mitko Mladenov, Gazmend Temaj, Asllan Cenaj, Burim Neziri, Qëndresa Beqiraj, Avdyl Krasniqi: Role of PGE 2 /EP 4 Receptor Signaling On The Effects Of Hyperoxia On Airway Smooth Muscle. Experimental Biology 2015, FASEB J, Boston - Scientific Sessions; 03/2015.
21. Ramadan Sopi, Mitko Mladenov, Ismail Dreshaj, Burim Neziri, Mirsad Mehmeti, Kemajl Bislimi, Muharrem Jakupaj: Role of PGE2/EP2 Receptor Signaling on The Effects of Neonatal Hyperoxia on Airway Smooth Muscle. The FASEB Journal - Scientific Sessions, 06/2015
22. Rudolph Schubert, Johannes Schmid, Bettina Mueller, David Heppeler, Dina Gaynullina, Mitko Mladenov: BK channels limit nitric oxide-induced reduction of vessel contractility. ISRA 2014; 11th International Symposium on Resistance Arteries - from molecular machinery to clinical challenges, Banff – Canada, - Scientific Sessions, 09/2014.
23. Ramadan B Sopi, Syed Zaidi, Mitko Mladenov, Gazmend Temaj, Floran Sahiti, Muharrem Jakupaj: Hematin Supplementation Protects Against Hyperoxia-Induced Airway Hyper-responsiveness. The FASEB Journal no. 1 Scientific Sessions 04/2014.
24. Radoslava Emilova, Daniela Dimitrova, Teodora Daneva, Mitko Mladenov, Rudolf Schubert, Hristo Gagov: Cystathionine gamma-lyase reverses perivascular adipose tissue dependent relaxation in skeletal muscle arteries of diabetic rats. St. Kliment Days-Sofia; 11/2013.
25. Ramadan B Sopi, Mitko Mladenov, Icko Gjorgoski, Syed I A Zaidi, Muharrem Jakupaj: L-Citrulline Protects Against Hyperoxia-Induced Increase in Airway Contractile Responses. The FASEB Journal - Scientific Sessions 01/2011.
26. Johanna Schleifenbaum, Olga Zavaritskaya, Nadezda Voblova, Torsten Gloe, Reinhard Kluge, Mitko Mladenov, Hristo Gagov, Gabor Fesu’s Christopher S Crean, Aliso Viejo, CA, Maik Gollasch Rudolf Schubert: Role of KCNQ Channels in Impaired Periadventitial Vasoregulation and Associated Hypertension. High Blood Pressure Research. Scientific Sessions Hypertension; 11/2010
27. Ramadan B Sopi, Icko Gjorgoski, Mitko Mladenov, Azem Lajçi, Muharrem Jakupaj: Role of L-Citrulline/L-Arginine Cycle in Hyperoxia-Induced Decrease of Airway Smooth Muscle Relaxation. FASEB-Scientific Sessions; 04/2010
28. Hadzi-Petrusev N, Mladenov M, Davceva O, Sterjovska-Aleksovska A, Spasov M, Dodevska D, Stojchevska E, Gjorgoski I: Protective role of vitamins E and C in carbon tetrachloride induced acute liver damage. 17th Meet Bal Clin Lab Fed, Ohrid; 09/2009
29. Gjorgoski I, Peshevska S, Mladenov M, Hadzi-Petrusev N, Atanasovska N, Spasov M, Davceva O: PGE2 concentration in tooth pulp tissue as a marker for the effectiveness of different types of treatment for periodontopathy. 17th Meet Bal Clin Lab Fed, Ohrid; 09/2009
Раководење и учество во меѓународни научно-истражувачки проекти
1. (2023-2025). Hyper-gravity and microgravity impact upon mechanosensitive channel gene transcripts in animal and human cardiac cells. RNSF – Russian Federation. Grant No. 573-229562. (учесник во својство раководител на група)
2. (2023-2025). The mechanism of action of nitric oxide as a first detected modulator of mechanically-gated channels. RNSF – Russian Federation. Grant No. 222-554492. (учесник во својство раководител на група)
3. (2019-2022). Transcriptomic profile of the mechanosensitive ion channelome in animal and human cardiac cells. RNSF – Russian Federation. Grant No. 100-211439. (учесник во својство раководител на група)
4. (2022-2023). The impact of hyperoxia on VIP/cAMP-PKA signaling in airways of neonatal rats. MESTRK – Grant No. 2-2459-11. (надворешен научен консултант)
5. (2019-2022). Transcriptomic profile of the mechanosensitive ion channelome in animal and human cardiac cells – RNSF – Russian Federation. Grant No. 128-432421. (учесник во својство раководител на група)
6. (2016-2017). Effect of polyphenols: resveratrol and quercetin on airway hyperresponsiveness induced by hyperoxia in neonatal rats”. MESTRK – Grant No. 2-1161. (надворешен научен консултант)
7. (2014-2015). PGE2-EP signaling and hyperoxia-induced impaired airway relaxation. MESTRK - Grant No. 2-7042. (надворешен научен консултант)
8. (2014-2016). Regulation of the activation and inactivation mechanisms of mechanically gated ion channels in cardiac fibroblasts affects the occurrence of arrhythmia and fibrillation. RNSF – Russian Federation. Grant No. 223-293764 (учесник во својство раководител на група)
9. (2012-2014). The role of intracellular signaling pathways for Ca2+ regulation and mechanically controlled channels in cardiomyocytes in the onset of sudden cardiac death syndrome. RNSF – Russian Federation. Grant No. 490-100901 (учесник во својство раководител на група)
10. (2004-2007). Ghrelin as a contractile regulator in small arteries. BMS. Grant No. 2004-743653 (учесник)
Раководење на домашни научно-истражувачки проекти
1. 2012-2013: Влијанието на продуктите од метаболизмот на арахидонската киселина врз сигнализацијата на грелинот кај малите артерии. Од програмата на УКИМ за подршка на научната активност на единиците.
Раководител на академски проекти финансирани од DAAD – СР. Германија
1. (2011-2012). Establishment of new academic and scientific cooperation between the partners from Balkan countries. (DAAD)- Universität Heidelberg, Center for Biomedicine and Medical Technology Mannheim, Heidelberg, Germany. (Раководител за Р. Македонија)
2. (2013-2014). “Academic synapsing in the Balkans”, within the DAAD program “Akademischer Neuaubau Südosteuropa (Stabilitätspakt SOE) ZV ab 2014”. (Раководител за Р. Македонија)
Раководител на проект за компанијата Веда Инженеринг за развој на нови системи за гасење на пожар:
1. Toxicity test for Veda Macedonian company:
A 15-min inhalation test using rats for assessing the potential for short-term toxicity to humans following the accidental release of a powdered aerosol, performed according to the guidelines of: EN 15276-2:2019 - Fixed firefighting systems - Condensed aerosol extinguishing systems - Part 2: Design, installation and maintenance (Annex B) and U.S. EPA Health Effects Test Guidelines OPPTS 870.1300 Acute Inhalation Toxicity.
